Page 60 - Livre électronique du congrès national de pneumologie 2022

Spirometry and body plethysmography (BP) were performed before and after BD. Proximal obstructive
performed before and after BD. Proximal obstructive defect (POD) was defined by FEV1/forced vital
defect (POD) was defined by FEV1/ forced vital capacity (FVC) <Lower limit of normal. Significant BDR
capacity (FVC) < Lower limit of normal. Significant was established according three definitions of: the
bronchodilator responsiveness (BDR) was AE21, the ATS/ERS 2005 (AE05) (increase of FEV1 or FVC
established according the definition of the GINA by 200 ml and 12% of the initial value) and the GINA
2021 (G21) (increase of FEV1 by 12 % of the predicted 2021 (G21) (increase of FEV1 by 12% of the predicted
value). LH was detected if the residual volume (RV) > value).For statistical purpose, we have used the SPSS
upper limit of normal. DLH was defined by a 20. A p<0.05 was significant.
decrease of RV more than 10 % after BD. For statistical
purpose, we have used the SPSS 20. A p < 0.05 was RESULTS:
significant. Among 200 included children (130 M/70F), 74.5% had
RESULTS: One hundred eighty children (117 M/63F) a POD. The median age was of 9.5 years. In the all
were included. The mean age was 10 years (±2,57). population, the percentage of BDR by AE21 was 36%
significantly higher than those of AE05 (35%) and G21
The percentage of POD and LH were respectively (24.5%) (p<0.05).These percentages were higher
76.1 % and 67.8 % of children. LH was dynamic in 47.2 among children with POD respectively 45% by AE21,
%. There was no significant association between 45% by AE05 and 31% by G21 (P<0.05). The Cohen
DLH and BDR in asthmatic children. 76.5% (N=65) of Kappa test has shown a k value of 0.803, 0.732 and
patients with DHL had no presented significant BDR
while 53.5 % of patients with BDR hadn’t DLH. 0.681 respectively between AE21 and AE05, A21 and
G21 and finally AE05 and G21.
CONCLUSION : The DLH has a clinical and
therapeutic implication but doesn’t confirm the CONCLUSION :
asthma diagnosis in children. The BDR assessment depends on the scholarly

P21. EVALUATION OF THE CLINICAL IMPACT society. The AE21 definition provides a significantly
higher BDR rate than AE05 and G21 ones. Prospective
OF THE REVISED BRONCHODILATOR randomized studies would help standardize the

RESPONSIVENESS OF THE ATS/ERS 2021 ON interpretation of BDR in children.

ASTHMATIC CHILDREN P22. IMPACT DE L’HYPEREOSINOPHILIE
SANGUINE SUR LA SEVERITE ET LE CONTROLE DE LA
Fatma ELLEUCH , Rim KAMMOUN, Fatma Zahra SIDINA, Leila
TRIKI , Kaouthar MASMOUDI MALADIE ASTHMATIQUE.

Service d'exploration fonctionnelle - CHU Habib Elfidha S ; Habouria C ; Belloumi N ; bachouch I ; Bejaoui T ;
BOURGUIBA - Sfax Jelassi W ; Chermiti F ; Fenniche S

INTRODUCTION : SERVICE DE PNEUMOLOGIE PAVILLON 4, HOPITAL ABDERRAHMEN
MAMI, ARIANA TUNISIE
The ATS/ERS 2021 (AE21) proposed a new definition
of the bronchodilator (BD) responsiveness (BDR)
basing on the increase of the forced expiratory INTRODUCTION :
volume in 1 second (FEV 1) over 10% of the predicted L'éosinophilie sanguine, déterminant majeur de la
value. réaction inflammatoire de la maladie asthmatique,

OBJECTIVES : To assess whether the AE21 BDR est utilisée comme un biomarqueur intéressant pour
definition is valid or not in asthmatic children. identifier un phénotype particulier d’asthme.
METHODS : We have conducted a retrospective OBJECTIF :
study, involving asthmatic children in the Physiology Étudier l’impact de l’hyperéosinophilie sanguine sur
and functional exploration department of Habib la sévérité et le contrôle de la maladie asthmatique.
Bourguiba hospital of Sfax. Spirometry was

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